Absence of Evidence and Evidence of Absence in the FLASH Trial: A Bayesian Reanalysis

Available on https://psyarxiv.com/4pf9j, this is a comment on a recent article in JAMA (Futier et al., 2020). The multicenter FLASH trial1 concluded that “Among patients at risk of postoperative kidney injury undergoing major abdominal surgery, use of HES [hydroxyethyl starch] for volume replacement therapy compared with 0.9% saline resulted in no significant difference in a …