scATACseq data are very sparse. It is sparser than scRNAseq. To do clustering of scATACseq data, there are some preprocessing steps need to be done.
I want to reproduce what has been done after reading the method section of these two recent scATACseq paper:
- A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility Darren et.al Cell 2018
- Latent Semantic Indexing Cluster Analysis
In order to get an initial sense of the relationship between …